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Semaglutide (CagriSema) The most extensively studied cagrilintide combination pairs it with semaglutide: The CagriSema combination demonstrates that adding amylin pathway activation to GLP-1 agonism produces substantially greater weight loss than GLP-1 therapy alone[9]

However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

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